Clinical Science

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  • Hoon Kook교수님 사진
  • Hoon Kook

    Departmant  Pediatrics
    Major  Pediatric Hematology, Bone Marrow Failure Syndrome, Pediatric Oncology, Hematopoietic Stem Cell Transplantation
    E-mail  hoonkook@jnu.ac.kr Homepage  

Research

1. Han DK, Baek HJ, Kim SY, Hwang TJ, Kook H. Implication of early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation in children with leukemia. Yonsei Med J 54(1):62-70, 2013
2. Seo JY, Song JS, Lee KO, Won HH, Kim JW, Kim SH, Lee SH, Yoo KH, Sung KW, Koo HH, Kang HJ, Shin HY, Ahn HS, Han DK, Kook H, Hwang TJ, Lyu CJ, Lee MJ, Kim JY, Park SS, Lim YT, Kim BE, Koh KN, Im HJ, Seo JJ, Kim HJ on behalf of the Korea Histiocytosis Working Party.     Founder Effects in Two Predominant Intronic Mutations of UNC13D, c.118-308C>T and c.754-1G>C Underlie the Unusual Predominance of Type 3 Familial Hemophagocytic Lymphohistiocytosis (FHL3) in Korea. Ann Hematol 2013;92(3):357-64
3. Park M, Lee SH, Lee YH, Yoo KH, Sung KW, Koo HH, Kang HJ, Park KD, Shin HY, Ahn HS, Chung NG, Cho B, Kim HK, Koh KN, Im HJ, Seo JJ, Han DK, Baek HJ, Kook H, Hwang TJ, Lee EK, Hah JO, Lim YJ, Jung HJ, Park JE, Jang MJ, Chong SY, Oh D. Pre-engraftment Syndrome after Unrelated Cord Blood Transplantation: a Predictor of Engraftment and Acute Graft-versus-host Disease. Biol Blood Marrow Transplant 2013 Apr:19(4):640-6
4. Tran HT, Kim HN, Lee IK, Nguyen-Pham TN, Ahn JS, Kim YK, Lee JJ, Park KS, Kook H, Kim HJ. Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin A. J Korean Med Sci. 2013 Feb;28(2):237-46.
5. Won EJ, Kim HR, Kim HY, Kook H, Kim HJ, Shin JH, Suh SP, Ryang DW, Shin MG. Diagnostic and Prognostic Value of Mitochondrial DNA Minisatellites after Stem Cell Transplantation. Biol Blood Marrow Transplant 2013; 19(6):918-924.
6. Kim M, Kook H, Park HJ, Ahn HS, Lee KC, Lee KS, Park SK, Lim JY, Kim HK, Han DK, Lee DS. Quantitative Comparison of CDKN2B Methylation in Pediatric and Adult Myelodysplastic Syndromes. Acta Haematol 2013;130(2):115-121.
7. Baek HJ, Kim JS, Yoon M, Lee JJ, Shin MG, Ryang DW, Kook H, Kim SK, Cho D. Ex vivo Expansion of Natural Killer Cells using Cryopreserved Irradiated Feeder Cells. Anticancer Res 33(5):2011-9, 2013
8.. Kim BE, Koh KN, Suh JK, Im HJ, Song JS, Lee JW, Kang HJ, Park KD, Shin HY, Choi HS, Lee SH, Yoo KH, Sung KW, Koo HH, Jung HL, Chung NG, Cho B, Kim HK, Lyu CJ, Baek HJ, Kook H, Park JE, Park HJ, Park BK, Yoo ES, Ryu KH, Lee KS, Kim HS, Lee JM, Lark ES, Yoon HS, Lee KC, Lee MJ, Lim YT, Kim HM, Park SK, Park JA, Kim SK, Park M, Lim YJ, Lee YH, Seo JJ on behalf of the Korea Histiocytosis Working Party. Clinical Features and Treatment Outcomes of Langerhans Cell Histiocytosis: A Nationwide     Survey from Korea Histiocytosis Working Party. J Pediatr Hematol Oncol 36(2):125-33, 2014
9. Lee DH, Baek HJ, Kook H, Yoon TM, Lee JK, Lim SC. Clinical value of fine needle aspiration cytology in pediatric cervical lymphadenopathy patients     under 12-years-of-age. Int J Pediatr Otorhinolaryngol 78(1):79-81, 2014
10. Park M, Lee YH, Kang HR, Lee JW, Kang HJ, Park KD, Shin HY, Ahn HS, Baek HJ, Kook H, Hwang TJ, Lee JW, Chung NG, Cho B, Lim HK, Lee SH, Yoo KH, Sung KW, Koo HH, Koh KN, Im HJ, Seo JJ, Park JE, Lim YJ, Lyu CJ, Hah JO; on behalf of the Korean Cord Blood Transplantation Working Party. Unrelated Donor Cord Blood Transplantation for Non-malignant Disorders in Children and Adolescents. Pediatr Transplant 18(2):221-229, 2014
11. Park HJ, Park MR, Han M, Nam BH, Koh KN, Im HJ, Lee JW, Chung NG, Cho B, Kim HK, Yoo KH, Koo HH, Kang HJ, Shin HY, Ahn HS, Lim YT, Kook H, Lyu CJ, Hah JO, Park JE, Lim YJ, Seo JJ. Efficacy and Safety of Micafungin for the Prophylaxis of Invasive Fungal Infection During     Neutropenia in Children and Adolescents Undergoing Allogeneic Hematopoietic SCT. Bone Marrow Transplant 2014 Sep;49(9)1212-6
12. Kim HY, Kim HR, Kang MG, Trang NT, Baek HJ, Moon JD, Shin JH, Suh SP, Ryang DW, Kook H, Shin MG. Profiling of Biomarkers for the Exposure of Polycyclic Aromatic Hydrocarbons: Lamin-A/C Isoform 3, Poly[ADP-ribose] Polymerase 1, and Mitochondria Copy Number Are Identified as Universal Biomarkers. Biomed Res Int 2014;2014:605135. doi: 10.1155/2014/605135. Epub 2014 Jul 10.
13. Kim H, Park ES, Lee SH, Koo HH, Kim HS, Lyu CJ, Jun SE, Lim YT, Baek HJ, Kook H, Lee JW, Kang HJ, Park KD, Shin HY, Ahn HS. Clinical Outcome of Relapsed or Refractory Burkitt Lymphoma and Mature B-Cell Lymphoblastic Leukemia in Children and Adolescents. Cancer Res Treat 2014 46(4):358-365.
14. Koh KN, Im HJ, Chung NG, Cho B, Kang HJ, Shin HY, Lyu CJ, Yoo KH, Koo HH, Kim HJ, Baek HJ, Kook H, Yoon HS, Lim YT, Kim HS, Ryu KH, Seo JJ, The Korea Histiocytosis Working Party. Clinical Features, Genetics and Outcome of Pediatric Patients with Hemophagocytic Lymphohistiocytosis in Korea: Report of a Nationwide Survey from Korea Histiocytosis Working     Party. Eur J Haematol 2015; 94(1):51-59
15. Choi HW, Kim HR, Baek HJ, Kook H, Cho D, Shin JH, Suh SP, Ryang DW, Shin MG. Alteration of the SETBP1 Gene and Splicing Pathway Genes SF3B1, U2AF1, and SRSF2 in Childhood Acute Myeloid Leukemia. Ann Lab Med 2015;35(1):118-22.
16. Park M, Lee YH, Lee SH, Yoo KH, Sung KW, Koo HH, Kang HJ, Park KD, Shin HY, Ahn HS, Chung NG, Cho B, Kim HK, Koh KN, Im HJ, Seo JJ, Baek HJ, Kook H, Hwang TJ, Lee JM, Hah JO, Lim YJ, Jung HJ, Park JE, Kang MJ, Chong SY, Oh D, on behalf of the Cord Blood Transplantation Working Party of the Korean Society of Hematology. Cytomegalovirus infection in seropositive unrelated cord blood recipients: a study of 349 Korean     patients. Ann Hematol 2015; 93(3):481-489
17. Kim KB, Son HJ, Choi S, Hahm JY, Jung H, Baek HJ, Kook H, Hahn Y, Kook H, Seo SB. H3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiation. Nucleic Acids Res 2015;43(7):3509-23
18. Hyun SY, Park SY, Lee SY, Kook H, Paik SH, Jang IJ, Lee KS.     Efficacy, Safety, and Pharmacokinetics of Beroctocog alfa in Patients Previously Treated for Hemophilia A. Yonsei Med J 2015: 56(4):935-43  
19. Baek HJ, Kim DW, Phan MT, Kim JS, Yang J, Choi JI, Shin M-G, Ryang DW, Kim SK, Lee SH, Kook H, Cho D. Comparison of NK cell subsets and FcRg-deficient NK cells between cord and adult blood in the CMV-endemic Korean population. Ann Lab Med 2015(4);35:423-8.
20, Park JH, Choi HW, Seo BY, Kang MG, Kim SH, Baek HJ, Kook H, Shin MG. Immature Teratoma and Subsequent Acute Promyelocytic Leukemia in a Pediatric Patient with XYY syndrome. Ann Lab Med 2015(5): 35:544-547.
21. Seo JY, Lee KO, Yoo KH, Sung KW, Koo HH, Kim SH, Kang HJ, Park KD, Shin HY, Baek HJ, Kook H, Lyu CJ, Song JS, Lee MJ, Kim JY, Lim YT, Koh KN, Im HJ, Seo JJ, Kim HJ. Prevalence of type 5 Familial Hemophagocytic Lymphohistiocytosis are Rare in Korean and Novel Mutations in STXBP2. Clin Genet 2016; 89(2):222-7
22. Kang MG, Kim YN, Lee JH, Szardenings M, Baek HJ, Kook H, Kim HR, Shin MG. Clinicopathological Implications of Mitochondrial Genome Alterations in Pediatric Acute Myeloid Leukemia. Ann Lab Med 2016;36(2):101-10.
23. Kook H, Chung NG, Kang HJ, Im HJ. Acquired aplastic anemia in Korean children: treatment guidelines from the Bone Marrow Failure Committee of the Korean Society of Pediatric Hematology Oncology. Int J Hematol 2016:103(2):380-386
24. Lee JA, Jeon DG, Cho WH, Song WS, Yoon HS, Park HJ, Park BK, Choi HS, Ahn HS, Lee JW, Yoo KH, Sung KW, Koo HH, Kang HJ, Park KD, Shin HY, Koh KN, Im HJ, Seo JJ, Lim YJ, Baek HJ, Kook H. Higher gemcitabine dose was associated with better outcome of osteosarcoma patients receiving     Gemcitabine-Docetaxel chemotherapy. Pediatr Blood Cancer 2016; Sep; 63(9): 1552-1556
25. Koh KN, Yoo KH, Im HJ, Sung KW, Koo HH, Kim HS, Han JW, Yoon JH, Park HJ, Park BK, Baek HJ, Kook H, Lee JA, Lee JM, Lee KC, Kim SK, Park M, Lee YH, Lyu CJ, Seo JJ. Characteristics and Outcomes of Second Malignant Neoplasms After Childhood Cancer Treatment: A Multi-center Retrospective Survey. J Korean Med Sci 2016;31:1254-1261

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