Basic Medical Science

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  • Hoon Hyun교수님 사진
  • Hoon Hyun

    Departmant  Biomedical Sciences
    Major  Molecular imaging, Drug delivery system, Biomaterials and Cancer therapy
    E-mail  hhyun@jnu.ac.kr Homepage  

Research

1. Hyun H, Lee S, Lim W, Jo D, Jung JS, Jo G, Kim SY, Lee DW, Um SW, Yang DH, Chun HJ. Engineered beta-cyclodextrin-based carrier for targeted doxorubicin delivery in breast cancer therapy in vivo. J Ind Eng Chem. 2018; in press.
2. Lee S, Lim W, Jung JS, Jo D, Jo G, Park MH, Hyun H. Surface charge modification of polyethyleneimine for enhanced renal clearance and bioimaging. Macromol Res. 2018; in press.
3. Hyun H, Park MH, Lim W, Kim SY, Jo D, Jung JS, Jo G, Um S, Lee DW, Yang DH. Injectable visible light-cured glycol chitosan hydrogels with controlled release of anticancer drugs for local cancer therapy in vivo: a feasible study. Artif Cells Nanomed Biotechnol. 2018; in press.
4. Yoon SJ, Yoo Y, Nam SE, Hyun H, Lee DW, Um S, Kim SY, Hong SO, Yang DH, Chun HJ. The cocktail effect of BMP-2 and TGF-β1 loaded in visible light-cured glycol chitosan hydrogels for the enhancement of bone formation in a rat tibial defect model. Mar Drugs. 2018; 16(10):351.
5. Yoo Y, Yoon SJ, Kim SY, Lee DW, Um S, Hyun H, Hong SO, Yang DH. A local drug delivery system based on visible light-cured glycol chitosan and doxorubicin⋅hydrochloride for thyroid cancer treatment in vitro and in vivo. Drug Deliv. 2018; 25(1):1664-1671.
6. Yoo Y, Hyun H, Yoon SJ, Kim SY, Lee DW, Um S, Hong SO, Yang DH. Visible light-cured glycol chitosan hydrogel dressing containing endothelial growth factor and basic fibroblast growth factor accelerates wound healing in vivo. J Ind Eng Chem. 2018; 67:365-372.
7. Fu Y, Tsauo J, Sun Y, Wang Z, Kim KY, Lee SH, Kim DY, Jing F, Lim D, Song HY, Hyun H, Choi EY, Developmental endothelial locus-1 prevents development of peritoneal adhesions in mice. Biochem Biophys Res Commun. 2018; 500(3):783-789.
8. Uong TN, Lee KH, Ahn SJ, Kim KW, Min JJ, Hyun H, Yoon MS. Real-time tracking of ex vivo-expanded natural killer cells toward human triple-negative breast cancers. Front Immunol. 2018; 9:825.
9. Ryu HW, Lim W, Jo D, Kim S, Park JT, Min JJ, Hyun H, Kim HS. Low-dose Evans blue dye for near-infrared fluorescence imaging in photothrombotic stroke model. Int J Med Sci. 2018; 15(7):696-702.
10. Lee HD, Shin JG, Hyun H, Yu BA, Eom TJ. Label-free photoacoustic microscopy for in-vivo tendon imaging using a fiber-based pulse laser. Sci Rep. 2018; 8(1):4805.
11. Lee S, Lim W, Jo D, Jung JS, Kim S, Jo G, Min JJ, Choi EY, Hyun H. Near-infrared fluorescent sorbitol probe for tumor diagnosis in vivo. J Ind Eng Chem. 2018; 64:80-84.
12. Wada H, Hyun H, Bao K, Lee JH, Fakhri GE, Choi Y, Choi HS. Multivalent mannose-decorated NIR nanoprobes for targeting pan lymph nodes. Chem Eng J. 2018; 340:51-57.
13. Noh I, Lee DY, Kim H, Jeong CU, Lee Y, Ahn JO, Hyun H, Park JH, Kim YC. Enhanced photodynamic cancer treatment by mitochondria-targeting and brominated near-infrared fluorophores. Adv Sci. 2018; 5(3):1700481.
14. Park S, Choi KS, Kim D, Kim W, Lee D, Kim HN, Hyun H, Lim KT, Kim JW, Kim YR, Kim J. Controlled extracellular topographical and chemical cues for acceleration of neuronal development. J Ind Eng Chem. 2018; 61:65-70.
15. Kim W, Kim D, Park S, Lee D, Hyun H, Kim J. Engineering lotus leaf-inspired micro- and nanostructures for the manipulation of functional engineering platforms. J Ind Eng Chem. 2018; 61:39-52.
16. Park MH, Lim W, Jo D, Jung JS, Kim S, Kim J, Lim HS, Lee JS, Min JJ, Hyun H. Rapid differential diagnosis of breast microcalcification using targeted near-infrared fluorophores. Adv Healthc Mater. 2018; 7(7):1701062.
17. Kim D, Park M, Jang H, Hyun H, Lim W. Chemoresistance to 5-FU inhibited by 635 nm LED irradiation in CD133+ KB cell line. Lasers Med Sci. 2018; 33(1):57-66.
18. Lee DW, Jo J, Jo D, Kim J, Min JJ, Yang DH, Hyun H. Supramolecular assembly based on host-guest interaction between beta-cyclodextrin and adamantane for specifically targeted cancer imaging. J Ind Eng Chem. 2018; 57:37-44.
19. Lee G, Ko Y, Park M, Kim B, Hyun H, Lim W. Recombinant DNA Cloning of the Active Region of the Receptor Activator of NF-κB Ligand (RANKL) Gene and its Role in Osteoclastogenesis. Biotechnol Bioproc E. 2017; 22(6):686-692.
20. Lee S, Lim W, Ryu HW, Jo D, Min JJ, Kim HS, Hyun H. ZW800-1 for assessment of blood-brain barrier disruption in a photothrombotic stoke model. Int J Med Sci. 2017; 14(13):1430-1435.
21. Pham DH, Kim JS, Kim SK, Shin DJ, Uong NT, Hyun H, Yoon MS, Kang SJ, Ryu YJ, Cho JS, Yoon JH, Lee JS, Cho D, Lee SH, Park MH. Effects of ADAM10 and ADAM17 inhibitors on natural killer cell expansion and antibody-dependent cellular cytotoxicity against breast cancer cells in vitro. Anticancer Res. 2017; 37(10):5507-5513.
22. Lim W, Sohn H, Ko Y, Park M, Kim B, Jo D, Jung JS, Yang DH, Kim J, Kim OJ, Kim D, Moon YL, Min JJ, Hyun H. Real-time in vivo imaging of metastatic bone tumors with a targeted near-infrared fluorophore. Oncotarget. 2017; 8(39):65770-65777.
23. Yoon SJ, Hyun H, Lee DW, Yang DH. Visible light-cured glycol chitosan hydrogel containing a beta-cyclodextrin-curcumin inclusion complex improves wound healing in vivo. Molecules. 2017; 22(9):1513.
24. Yun M, Kim DY, Lee JJ, Kim HS, Kim HS, Pyo A, Ryu Y, Kim TY, Zheng JH, Yoo SW, Hyun H, Oh G, Jeong J, Moon M, Min JH, Kwon SY, Kim JY, Chung E, Hong Y, Lee W, Kim HS, Min JJ. A high-affinity repebody for molecular imaging of EGFR-expressing malignant tumors. Theranostics. 2017; 7(10):2620-2633.
25. Jo D, Hyun H. Structure-inherent targeting of near-infrared fluorophores for image-guided surgery. Chonnam Med J. 2017; 53(2):95-102.
26. Lee J, Park M, Ko Y, Kim B, Kim O, Hyun H, Kim D, Sohn H, Moon YL, Lim W. Ectopic overexpression of CD133 in HNSCC makes it resistant to commonly used chemotherapeutics. Tumor Biol. 2017; 39(4):1-12.
27. Wada H, Hyun H, Kang H, Gravier J, Henary M, Bordo MW, Choi HS, Frangioni JV. Intraoperative near-infrared fluorescence imaging of thymus in preclinical models. Ann Thorac Surg. 2017; 103(4):1132-1141.
28. Seonwoo H, Bae W, Park S, Kim HN, Choi KS, Lim KT, Hyun H, Kim JW, Kim J, Chung JH. Hierarchically micro- and nanopatterned topographical cues for modulation of cellular structure and function. IEEE T Nanobiosci. 2016; 15(8):835-842.
29. Garg P, Pandey S, Kim H, Seonwoo H, Park S, Choi KS, Jang K, Hyun H, Choung P, Kim J, Chung JH. Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery. RSC Adv. 2016; 6:111233-111238.
30. Ashitate Y, Levitz A, Park MH, Hyun H, Venugopal V, Park G, Fakhri GE, Henary M, Gioux S, Frangioni JV, Choi HS. Endocrine-specific NIR fluorophores for adrenal gland targeting. Chem Commun. 2016; 52(67):10305-10308.
31. Owens EA, Hyun H, Dost TL, Lee JH, Park G, Pham DH, Park MH, Choi HS, Henary M. Near-infrared illumination of native tissue for image-guided surgery. J Med Chem. 2016; 59(11):5311-5323.
32. Hyun H, Henary M, Gao T, Narayana L, Owens EA, Alyabyev S, Lee JH, Park G, Wada H, Ashitate Y, Bordo MW, Frangioni JV, Choi HS. 700-nm zwitterionic near-infrared fluorophores for dual-channel image-guided surgery. Mol Imaging Biol. 2016; 18(1): 52-61.

Etc

Member of The Korean Society for Biomaterials, The Korean Society of Industrial and Engineering Chemistry, Korean Tissue Engineering and Regenerative Medicine Society, The Polymer Society of Korea, The Pharmaceutical Society of Korea, Optical Society of Korea